Structure and numbering of cytisineA) projection structure with -  Download Scientific Diagram

cytisine - Wiktionary

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Laburnum, which includes cytisine. It revealed teratogenic impact in rabbits and poultry. It is a respiratory stimulant, with nicotine-like activity, and a hallucinogenic. However, pharmacologically, cytisine seems a potential therapeutic utility in assisting smoking cessation. In addition, it has revealed analgesic, antihypertensive, inotropic, antispasmodic, antioxidant, and insecticidal activities.

The effects of poisonous dosages include weak point, lightheadedness, problems of motor coordination, muscular facial twitches, increased reflex level of sensitivity, mydriasis, shallow breathing, periodic urinary retention, and eventually, tonic-clonic convulsions followed by collapse and coma with respiration cessation, mainly brought on by paralysis of respiratory muscles. 485-35-8 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Harborne JB, Baxter H and Moss GP (1999 ).

2nd edition, TJ International Ltd, Padstow, UK. Rouden J, Lasne MC, Blanchet J, and Baudoux J (2014 ). Review: ()-Cytisine and Derivatives: Synthesis, Reactivity, and Applicationserome. Chem. Rev. 114: 712778. Tutka P, Zatoski W (2006 ). Review - Cytisine for the treatment of nicotine dependency: from a molecule to healing efficacy. Medicinal reports 58,777-798.

Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds  - Journal of Pharmacology and Experimental Therapeutics

Synthesis and initial medicinal evaluation of some cytisine derivatives. Farmaco, 1999, 54, 438451.

All about Cytisine - 485-35-8 - Biosynth Carbosynth

Cytisine for Smoking Cessation: A Literature Evaluation and a Meta-analysis Etter JFArch Intern Medication. 2006; 166:1553 -1559 To assess the effectiveness of an alkaloid derivative of the plant Cytisus laburnum L., or golden rain tree, called cytisine (not to be puzzled with cytosine or cysteine), a review of the literature and a meta-analysis were carried out.

The research studies, all from Bulgaria, Germany, Poland, and Russia, included a total of 4404 cigarette smokers treated with cytisine and 3518 controls. Quit/abstinence rates, based on survey (not biochemical) evaluation, varied from 13. 8% to 70% anywhere from 15 days to 14 months following treatment with cytisine.  nicorette inhaler -analysis of the 3 placebo-controlled trials revealed a chances ratio (OR) of 1.

21-3. 06) for short-term result of 4 weeks. A different meta-analysis of the 2 placebo-controlled trials that had long-term follow-up found a pooled OR of 1. 83 (95% CI, 1. 12-2. 99) for continued abstinence after 3-6 months. One placebo-controlled study reported abstaining rates 2 years post cytisine treatment with an OR of 1.

29-2. 43). The most typical type of cytisine is a tablet including 1. 5 mg of the active component. Suggested dosage is 6 tablets daily (overall of 9 mg of cytisine) for the very first 3 days with a steady taper to 2 tablets daily by day 25 at which point the treatment is stopped.